Inflamed fibronectin: an altered fibronectin enhances neutrophil adhesion
نویسندگان
چکیده
منابع مشابه
Inflamed fibronectin: an altered fibronectin enhances neutrophil adhesion.
Recent investigations have emphasized the role of activated granulocytes in mediating vascular endothelial injury in the pathogenesis of shock lung. In vitro studies have indicated that tight adherence of the neutrophil to the endothelium is crucial for the development of cellular injury. Fibronectin is critical to cell-to-substratum and cell-to-cell interactions. Since fibronectin resides in p...
متن کاملFibronectin matrix assembly enhances adhesion-dependent cell growth.
Cell growth control in non-transformed cells depends, in part, on adhesive interactions with the extracellular matrix. Following injury, excess or altered fibronectin deposition into the extracellular matrix may contribute to the pathogenesis of fibrosis and atherosclerosis by triggering changes in specific cell functions associated with wound repair, including cell proliferation and migration....
متن کاملFibronectin-independent Adhesion of Fibroblasts
Fibroblastic CHO cells readily adhere to fibronectin (Fn) coated substrata. From the parental cell population we have recently selected a series of adhesion variants (AD" cells) that cannot adhere to Fn substrata (Harper and Juliano. 1980 . J. Cell. Biol. 87:755-763) . However, AD" cells readily adhere to substrata coated with extracellular matrix material (ECM) derived from human diploid fibro...
متن کاملIntegrin-dependent cell adhesion to neutrophil extracellular traps through engagement of fibronectin in neutrophil-like cells
Neutrophil extracellular traps (NETs), originally recognized as a host defense mechanism, were reported to promote thrombosis and metastatic dissemination of cancer cells. Here we tested the role of integrins α5β1 and ανβ3 in the adhesion of cancer cells to NETs. Neutrophil-like cells stimulated with calcium ionophore (A23187) were used as a stable source of cell-free NETs-enriched suspensions....
متن کاملFibronectin glycosylation modulates fibroblast adhesion and spreading
The role of the carbohydrate residues of fibronectin concerning the specificities of that glycoprotein to interact with fibroblastic cell surfaces, gelatin, and heparin was examined. Tunicamycin was used to produce carbohydrate-depleted fibronectin; it was synthesized by cultured fibroblasts. Unglycosylated and glycosylated fibronectins were analyzed for their ability to bind gelatin and hepari...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Blood
سال: 1983
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v62.5.1063.1063